| abstract |
A method for preparing degarelix. Introducing a dipeptide fragment Fmoc-Pro-D-Ala-OH and using morpholine/DMF deprotection reagent can effectively control hydantoin impurities [4Aph(D/L-Hydantoinacetyl)5]Degarelix and [D-Pro 9]Deagarelix impurities. The method for preparing degarelix is simple in operation, easy in quality control, small in environmental pollution, and suitable for scale production. |