| abstract |
The present invention relates to the preparation of a hydrophobic medicinal auxiliary material and a drug-loaded fat emulsion, and in particular to a hydrophobic auxiliary material with the structural formula as shown below, wherein R is a hydrophobic natural compound or hydrophobic synthetic compound with one to three hydroxyl groups (n=1-3), R1 is an alpha-amino protecting group, and R2 is an amino acid side chain; when m=0, R reacts with an amino acid derivative with a protecting group by means of esterification to form a hydrophobic auxiliary material carrying the amino acid derivative with a protecting group; or, when m＝1, R first introduces an amino acid linking arm of different chain lengths (l=1, 2, 4, 6) by means of an ester group, and then introduces an amino acid derivative with a protecting group to form a hydrophobic auxiliary material carrying an amino acid derivative polypeptide with a protecting group. The introduction of an amino acid derivative with an aromatic, alkoxycarbonyl or acyl amino protecting group on the hydrophobic auxiliary material is conducive to increasing the solubility of the drug in the hydrophobic auxiliary material and improving the stability of the drug-loaded fat emulsion. |