| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3974068b7829f6e7f6fe642dcdf638fa |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-4277 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-650905 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6509 |
| filingDate |
2020-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91cad47680ad9e3163903128d636321a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b5a22f0dc70df71db5a2e89a4ef0437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf4146966895532c458bd85abbeabdb2 |
| publicationDate |
2020-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020248756-A1 |
| titleOfInvention |
Phosphine nitrogen ligand having multiple chiral centers, synthesis method therefor and use thereof |
| abstract |
Disclosed are a phosphine nitrogen ligand having multiple chiral centers, a synthesis method therefor and use thereof. The ligand has the axial chirality of a biaryl skeleton and the central chirality of a chiral amine. The chiral ligand is synthesized from commercially available raw materials by means of a simple five-step reaction, and the finally obtained diastereomeric product can be separated only by means of simple column chromatography or recrystallization. The synthesized chiral phosphine nitrogen ligand of the present invention can be used for catalyzing an asymmetric three-component coupling reaction of a terminal alkyne, an aldehyde and an amine, thereby realizing the efficient preparation of a chiral propargylamine compound having high optical activity. |
| priorityDate |
2019-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |