| abstract |
Disclosed are methods and compositions for the treatment of an individual having neurodegeneration associated with Gaucher' s disease and/or different forms of Parkinson' s Disease. The disclosed methods and compositions include administering an inhibitor of the C5a pathway to an individual in need thereof, in an amount sufficient to delay onset of and/or alleviate neurodegeneration in the individual having, or suspected of having, Gaucher's disease. Inhibitors of the C5a pathway may include C5a Receptor (C5aR) inhibitors, antagonists of C5aR1, C5aR2, muteins of C5a, and combinations thereof. |