| abstract |
Provided are: a production method in which the quality of a bifurcated lipid-linked oligonucleotide can be controlled; and an intermediate that is useful for the production method, has good stability, and is easy to manage and analyze. Specifically, this production method for a bifurcated lipid-linked oligonucleotide comprises a step for reacting an oligonucleotide with a compound represented by formula (II) (in the formula, Pro1-Pro4 each independently represent a protecting group, Pro1 and Pro2 or Pro3 and Pro4 may together form a protecting group, m, n, and p each independently represent an integer of 0-5, and Y represents a group or the like represented by formula: -P(OC2H4CN)(N(i-Pr)2)). |