http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020244530-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b75a05785dbfd86d27a87ddcdc5a524 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2020-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f705929e4b635d1a409837ac00ad6930 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_850c227774e234786167084a7830fbaf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04c00b66d2fc3e865104b061e2bd8402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dce36f616def2d1f1e1e86869e8b2f86 |
| publicationDate | 2020-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020244530-A1 |
| titleOfInvention | 5-pyrimidine-6-oxy-pyrazolopyridine derivative, preparation method therefor and application thereof |
| abstract | The present invention relates to a 5-pyrimidine-6-oxy-pyrazolopyridine derivative and pharmaceutically acceptable salts thereof, a preparation method therefor and an application thereof. The chemical structural formula (II) of the 5-pyrimidine-6-oxy-pyrazolopyridine derivative is shown in the figure. The derivative and pharmaceutically acceptable salts thereof block a TGF-β/ERK signaling pathway by activating a sGC-cGMP pathway, thereby exerting the anti-fibrosis effect thereof. Therefore, as a novel sGC agonist, the derivative can exert anti-fibrosis and anti-tissue remodeling effects by up-regulating cGMP levels, and thus becomes a new strategy for drug treatment of pulmonary fibrosis diseases. |
| priorityDate | 2019-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 486.