http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020242496-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61780a90f170fd21a26a423458183322 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 |
| filingDate | 2019-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d324291def86f27e4416cb67b0d4265 |
| publicationDate | 2020-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020242496-A1 |
| titleOfInvention | Method of treating pancreatic cancer |
| abstract | A method of treating pancreatic cancer (PAC) in cystic fibrosis (CF) patients is disclosed, wherein a combination of two drugs, digitoxin and parenteral vitamin C (PVC) is administered to the patient. The combination of the two drugs can profoundly inhibit cell growth in a unique cystic fibrosis pancreatic adenocarcinoma cell line, CFPAC-l(P). When correcting the CF state by transfecting these cells with [wildtype]CFTR (viz., CFP AC - 1 (PL J -4.7)), sensitivity to these two drugs, individually or in combination remains the same. However, their combination is synergistic, resulting in lower apparent IC50 (inhibitory concentration) values for each drug. The IC50 of vitamin C is lowered by 75-88%, and the IC50 of digitoxin is lowered by ca 50%. |
| priorityDate | 2019-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 388.