| abstract |
[Problem] To provide a novel fluorescent probe which can be used in a spray mode, has excellent specificity to sensitivity, also has immediacy, and enables the detection of brain tumor. [Solution] A fluorescent probe for use in the detection of brain tumor, which comprises a compound represented by formula (I) or a salt thereof: (in the formula, P1 represents an arginine residue, a histidine residue or a tyrosine residue, and P2 represents a proline residue or a glycine residue, wherein P1 is liked to an adjacent N atom to form an amide bond, and P2 is linked to P1 to form an amide bond; R1 represents 1 to 4 same or different substituents independently selected from the group consisting of a hydrogen atom and an alkyl group, a carboxyl group, an ester group, an alkoxy group, an amide group and an azide group each of which may be substituted; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group which may be substituted, or a halogen atom; R8 and R9 independently represent a hydrogen atom or an alkyl group; X represents O, Si(Ra)(Rb), Ge(Ra)(Rb), Sn(Ra)(Rb), C(Ra)(Rb) or P(=O)(Ra)； Ra and Rb independently represent a hydrogen atom, an alkyl group or an aryl group; and Y represents a C1-C3 alkylene group). |