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filingDate 2019-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2020-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020233102-A1
titleOfInvention Pharmaceutical composition for treatment of tumor or cancer, and application thereof
abstract Provided are a pharmaceutical composition for treatment of a tumor or cancer, and an application thereof. The pharmaceutical composition comprises an oncolytic rhabdovirus and a CD38 small molecule inhibitor such as rhein by means of direct local injection or systemic administration or intratumoral delivery. The oncolytic rhabdovirus has the property of recognizing tumor cells and would not cause damage to normal cells; moreover, the CD38 small molecule inhibitor can specifically inhibit the activity of T-cell receptor molecules; the use of the oncolytic rhabdovirus and the CD38 small molecule inhibitor in combination has significant advantages in safety and efficacy.
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priorityDate 2019-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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