| abstract |
Provided are a naphthoquinone fused triazole derivative, preparation method and application thereof. The naphthoquinone fused triazole derivative has a structure represented by the following formula (I), wherein X is C or N; R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 are each independently any one of hydrogen, halogen, hydroxyl, cyano, sulfydryl, amino, nitro, nitroso, alkyl, alkoxy, ester group, carboxyl and sulfonyl. Also provided is the application of the naphthoquinone fused triazole derivative or a pharmaceutically acceptable salt or hydrate thereof in preparation of a medicament for treating a disease with abnormal signal transduction of STAT3. |