| abstract |
[Problem] To provide a novel antitumor agent and a compounding agent. [Solution] Provided is an antitumor agent that contains as an active ingredient a glutathione concentration-decreasing agent or a glutathione S-transferase inhibitor and that is administrated at the same time as an effective amount of a compound (II), an antitumor agent that contains as an active ingredient a compound (II) and that is administered at the same time as an effective amount of a glutathione concentration-decreasing agent or a glutathione S-transferase inhibitor, or an antitumor agent that contains as active ingredients a compound (II) and a glutathione concentration-decreasing agent or a glutathione S-transferase inhibitor. (In the formula, R5 is a C1-6 straight-chain or branched alkyl group; R6 is hydrogen or halogen; R7 is a C1-6 straight-chain or branched alkyl group optionally bearing a substituent, the substituent being hydroxy or phenyl; and R8 is hydrogen or halogen.) |