| abstract |
A drug delivery vector, containing cell-penetrating peptide-modified liposomes and a polymer, the polymer being a positively charged polyamino acid. A pharmaceutical formulation in the form of a liposome complex is prepared using the drug delivery vector, the particle size being between 50 nm and 300 nm, being prepared by mixing a physical complex formed of the positively charged polyamino acid and one or more drug molecules with a liposome surface-modified with a cell-penetrating peptide, the pharmaceutical formulation being capable of effectively transfecting cells, particularly promoting the absorption of the drug into the brain via the nasal cavity, and thereby increasing the efficacy of the drug. |