| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-727 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 |
| filingDate |
2019-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79ef173a65cbba3ecb39a404445b38b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a52dec5c9315e1f69c27b9f8d7b690d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb6f2df6cbf5ed5e0c27507f3f42b705 |
| publicationDate |
2020-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020224042-A1 |
| titleOfInvention |
Cell culture method for improving curative effect and durability of chimeric antigen receptor t cell |
| abstract |
The present invention provides a cell culture method for improving the curative effect and the durability of a chimeric antigen receptor (CAR) T cell. A tyrosine kinase inhibitor dasatinib is added to reduce CAR-T cell activation signaling transmission, inhibit the terminal differentiation of the CAR-T cell, and increase proportions of a naive T cell and a central memory T cell in a CAR-T cell product while inhibiting the depletion tendency of the CAR-T cell. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022194224-A1 |
| priorityDate |
2019-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |