| abstract |
Disclosed is a pharmaceutical preparation in the granule form with a core particle and a coating layer covering the core particle, wherein the core particle contains a drug, a first core particle component, a second core particle component, and a surfactant. The drug is an aniline derivative represented by General Formula (I) [where W or S represents O], a pharmaceutically acceptable salt thereof, or a hydrate thereof. The first core particle component is at least one type of crystalline cellulose having a shape selected from a needle-like shape and a substantially columnar shape. The second core particle component is at least one type of substantially spherical pharmaceutically acceptable additive. This pharmaceutical preparation has excellent flowability sufficient for practical production and can contain a therapeutically effective amount of a poorly-water-soluble drug (CDK 9 inhibitor). |