| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-585
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B30-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2020-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29c08dd58b04391c940f26241dfe4b30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02b00ab2868024f0238fb9a242205341
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18bc09afef3b41165705613611b4d861 |
| publicationDate |
2020-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020212439-A1 |
| titleOfInvention |
Small molecule screening cellular assay using modified beads |
| abstract |
A method for screening a DNA-encoded library of chemical structures (2) for activity in a cellular target (11) wherein the chemical structures (2) of the library, the corresponding encoding DNA (4) and, optionally, a chemical probe (7/8/9) susceptible to the response molecule (12) are covalently linked to beads (1); the method comprising providing an incubation medium (13) or aliquot thereof comprising the cellular target (11) and exactly one or more than one bead (1) as defined above, releasing the chemical structures (2) from the bead(s) (1) in the incubation medium (13) or aliquots thereof by cleaving the structure linkers (3) and incubating the released chemical structures (2) and the cellular target (11); and sequencing the encoding DNA present or remaining on the bead(s) (1). A bead (1) suited for the method is also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022084486-A1 |
| priorityDate |
2019-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |