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filingDate 2020-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2020-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020206385-A1
titleOfInvention Improved methods and compositions for synthetic biomarkers
abstract The present disclosure encompasses embodiments of nucleic acids comprising genetic elements which are useful for the detection of diseased cells. In some aspects, the present disclosure provides for a method comprising: (a) administering to a subject a composition, wherein the composition induces expression of a biomarker in a diseased cell preferentially over expression of the biomarker in non-diseased cells in the subject such that a relative ratio of the biomarker expressed in the diseased cell over the non-diseased cells is greater than 1.0; (b) detecting the biomarker; and (c) using the biomarker detected in (b) to determine that the subject has the diseased cell at an accuracy of at least 70%.
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