| abstract |
The present invention relates to a formulation of composites comprised of yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-molecular-weight compounds, such as medicaments (drugs) or food supplements. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly-water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. The present invention further relates to a method of preparation of the composites by spray drying, and the use thereof. |