http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020200305-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c27f4a786895417d03d0b1045587100 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c5e9bdb7875405497fb88e6d021b53e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-616 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-616 |
| filingDate | 2020-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6d188a0b8a7b33b961b80b2a3dc90ba |
| publicationDate | 2020-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020200305-A1 |
| titleOfInvention | Use of pharmaceutical composition containing hydroxyurea |
| abstract | Provided is the use of a pharmaceutical composition containing hydroxyurea, wherein the hydroxyurea or a pharmaceutically acceptable salt thereof is used in the preparation of a drug for preventing and/or treating atherosclerosis. Experimental results show: after oral administration of a combination of hydroxyurea, aspirin and clopidogrel bisulfate, fat and porridge-like lesion regions on aortic intima are significantly reduced, the effect on atherosclerosis is obvious (plaque inhibition degree of 85％), the concentrations of blood glucose, triglyceride, total cholesterol, and low-density lipoprotein cholesterol are decreased, and glucose and lipid metabolism disorder is significantly improved; after oral administration of a combination of hydroxyurea, aspirin, clopidogrel bisulfate and atorvastatin calcium, fat and porridge-like lesion regions on aortic intima are further significantly reduced, and atherosclerosis is essentially cured (plaque inhibition degree of 91％). The combinations of drugs at this dose have an outstanding therapeutic effect in the prevention and/or treatment of atherosclerosis. |
| priorityDate | 2019-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 138.