| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b7e611c3edd73d4125e09dcd1fb295e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N2005-0661
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F9-009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F9-008 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F9-0017
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N5-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F9-0079
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F9-007 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F9-007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F9-009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F9-008 |
| filingDate |
2020-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d27477de47fdc78cd85c79a3911bae04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7077a0ddba572367b34087ca966d747e |
| publicationDate |
2020-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020198421-A1 |
| titleOfInvention |
Corneal crosslinking with catalyst distribution control |
| abstract |
In corneal crosslinking, the anterior surface of the cornea of the eye is maintained in contact with a first liquid having a first concentration of a crosslinking catalyst such as riboflavin, so that the catalyst enters the cornea and forms a first concentration profile (110) in the corneal stroma. The anterior surface of the cornea is then maintained in contact with one or more additional liquids having concentration of the catalyst lower than the first concentration so that the catalyst forms a second concentration profile (116) in the stroma. In the second concentration profile, the maximum concentration of the catalyst desirably is posterior to the anterior surface of the cornea. The cornea is irradiated and crosslinked. The second concentration profile facilitates crosslinking deep within the stroma. |
| priorityDate |
2019-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |