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filingDate 2020-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62ff7b5cc9482e70513556b35e30ec49
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publicationDate 2020-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020193506-A1
titleOfInvention Chimeric antigen receptors, vectors coding for such receptors and their use in the modification of t cells
abstract The present invention relates to achimeric antigen receptor comprising at least the following components: a) a peptidic structure capable of binding to a ligand; b) an extracellular spacing structure; c) a transmembrane domain; d) none or at least one co-stimulatory domain; and e) at least a TCR-derived activatory domain whereby a second TCR-derived activatory domain comprises the amino acid sequence RKGQRDLY (SEQ ID NO:1),which is capable to bind the lymphocyte specific Src kinase in a phosphorylation independent manner and its use in vectors for transducing T cells which are useful in the treatment of diseases, in particular tumors.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022084491-A1
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