| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c73590e943149b538924729392c68a5d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate |
2020-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dce103f50ede1da1b6f803c4a08de4dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcb665da3d3353b9fc4caef660f54e20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_485145874f38e8daf0f39614ac6c7ad2 |
| publicationDate |
2020-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020177627-A1 |
| titleOfInvention |
Bispecific antibody |
| abstract |
Provided is a bispecific antibody, in particular a bispecific antibody simultaneously targeting tumour cell surface antigens and immune checkpoint proteins. The antibody comprises a first binding domain targeting the immune checkpoint proteins of a first target cell and a second binding domain binding with tumour cell surface antigens of a second target cell surface. The antibody binds with high affinity to tumour cell surface antigens by means of polypeptides, aggregating fragments (e.g. PD-L1 antibodies) targeting the immune checkpoints fused thereto onto the tumour cells, or near to same and in the tumour microenvironment, exerting the specific killing effect of the effector cells on tumour cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115052892-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114539416-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022078277-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114195900-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021244552-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023020315-A1 |
| priorityDate |
2019-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |