| abstract |
The present disclosure generally relates to novel compositions and methods for improving the efficiency of adoptive cell therapies and enhancing CAR-T cell functionality by simultaneously targeting different epitopes on a same antigen molecule associated with or specific for a target cell, e.g., cancer cell. Some embodiments of the disclosure provides recombinant cells containing one or more chimeric antigen receptors (CARs) directed to different epitopes present on a same target antigen. Also provided are nucleic acids encoding the disclosed CARs, recombinant cells expressing the same, pharmaceutical compositions containing the disclosed nucleic acids and/or recombinant cells, and methods useful for modulating an activity of a target cell, e.g., cancer cell, as well as methods for treating a disease. |