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publicationDate 2020-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020176790-A1
titleOfInvention Hydrogel compositions and methods for treatment of malignancies
abstract Methods and compositions for treatment of malignancies are provided. The methods utilize implantation of engineered, programmable hydrogel depots capable of long-term molecule release into close proximity of the tumor. By providing gradients of immune cell chemokines and releasing immune checkpoint inhibitors, the hydrogel implants are effective at elimination of tumor cells via immune cell-mediated cell death.
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