| abstract |
The present invention relates to the pharmaceutical and chemical field, and provided is a method for preparing siponimod. The method of the present invention relates to taking 3-bromo-4-methylacetophenone as a starting material, and performing steps such as bromination, reaction with azetidine-3-carboxylic acid methyl ester or a salt thereof and a vinyltrifluoroborate, alkene reduction, and hydrolysis to obtain siponimod, and is a novel method for preparing siponimod. The product obtained in preparation with the method has the feature of being high in purity, high in yield rate, low in cost, simple in operation, and stable in process. |