| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9bda5572019d627187b8ed64b1c41878 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0646
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 |
| filingDate |
2020-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dd88f64332c04f40c190d26d7c2dd25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_115a799084504fb1655628f52c15aaf3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f5230e782fdf6137da46f2aa51f60d4 |
| publicationDate |
2020-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020165402-A1 |
| titleOfInvention |
Gd2-upregulation by ezh2 inhibition in cancer therapy |
| abstract |
The present invention relates an Enhancer of Zeste Homolog 2 (EZH2) inhibitor for use in a method of treating a solid tumor in a subject, wherein the method further comprises the administration of a G D2 -specific CAR-T cell or CAR-NK cell or a G D2 -specific antibody or antibody derivative to the subject. Further, the present invention relates to a G D2 -specific chimeric antigen receptor (CAR-) T cell or CAR-NK cell for use in a method of treating a solid tumor in a subject, wherein (i) the method further comprises the administration of an EZH2 inhibitor to the subject; and/or (ii) the subject has been and/or is treated with an EZH2 inhibitor. Additionally, the present invention relates to methods for increasing the surface expression of G D2 in solid tumor cells and kits and kits-of-part comprising an EZH2 inhibitor and a G D2 -specific CAR-T cell or a G D2 -specific CAR-NK cell. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114940969-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112626236-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022246942-A1 |
| priorityDate |
2019-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |