| abstract |
Disclosed are compounds of formula (Ib) or (Vc), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ib) or (Vc) and methods of using the same for treating cancer, respiratory inflammatory disease, and inhibiting arginase; wherein R 1 is -H or -C(O)CH(R 1a )NHR 1b ; and R 1a is selected from -H, -(C 1 -C 4 ) alkyl and CH 2 OR 1c ; R 1b is -H; or alternatively, R 1a and R 1b , together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R 1c is H or -CH 3 . |