| abstract |
The invention relates to an enteric release system for releasing glucosinolate in the colon to increase bioavailability of allyl-isothiocyanate in the body of human subject. It comprises of a) a solid core made of glucosinolate obtained from the extract prepared from prepared from mustard seed, mustard cake or mustard bran or a combination thereof and b) an enteric protective coating over said core. The glucosinolate derived from mustard extract contains 20% to 90% sinigrin which is proved to have anticancer activity. The delivery systems used here includes excipients. It is dispensed in the form of hard gel capsule, soft gel capsule, tablet, beadlets, mini tablet, granule, powder and pills and the dosage ranges from 200 mg to about 2000 mg to a human subject. The enteric coating targets the sinigrin for release in large intestine where sinigrin is converted to AITC and increases its bioactivity. |