| abstract |
Compositions and methods for the treatment of cancer are provided. Specifically, the disclosure provides a method for treating and/or inhibiting cancer or neoplasia in a subject, the method comprises contacting cancer cells obtained from the subject to be treated with an inhibitor of an immunity suppressing tumor protein; rendering the cancer cells proliferation-incompetent (e.g.,by irradiation); and administering the treated cancer cells and a checkpoint inhibitor to the subject, wherein the inhibitor of an immunity suppressing tumor protein is an inhibitor of Inhibitor of differentiation protein 2 (Id2), Myc, and/or apolipoprotein E (ApoE). |