| abstract |
A fibroblast growth factor 21 variant, and fusion protein and use thereof. The fusion protein comprises a fibroblast growth factor 21 variant, a GLP-1 variant, and an FC sequence. The provided fusion protein features high activity, long half-life, and a new structure, and can significantly reduce blood sugar and weight and improve fat metabolism. Also provided are a fusion gene, an expression construct, and a host cell comprising an encoding nucleotide sequence of the fusion protein, and an application of the fusion protein, fusion gene, expression construct, and host cell, or a pharmaceutical composition in the preparation of a drug for treating obesity, hyperlipidemia, diabetes, and cardiovascular and cerebrovascular diseases. |