| abstract |
Disclosed are a ternary complex nanometer system, a preparation method therefor and a use thereof. The system comprises an iron compound, a benzene-ring-containing micromolecule anti-tumor active compound and a polyphenol compound, wherein the weight ratio of the three is 1-4 : 2-10 : 5-20. In comparison with the prior art, different micromolecule compounds or medicines can be stably assembled merely by means of physical assembling. Not only does a formed complex nanometer medicine have the anti-tumor therapeutic effect of the micromolecule anti-tumor active compound, but same also has a ferroptosis therapeutic effect, which is mediated by the iron compound and the polyphenol compound on the basis of an intracellular Fenton reaction. Furthermore, the formed new-type complex nanometer medicine also has an outstanding photothermal effect, and can integrate chemotherapy, ferroptosis therapy and photothermal therapy into one, wherein the three have a synergistic effect, increase the effects of one another and achieve an all-in-one combined anti-tumor therapeutic effect. |