| abstract |
Disclosed are a proteolysis targeting chimeric molecule, a preparation method, and an application. The provided proteolysis targeting chimeric molecule can inhibit the expression of BCR-ABL and/or CRBN protein in BCR-ABL and/or CRBN positive leukemia K562 cells to varying degrees, and thus can be used for preparing a drug for treating BCR-ABL and/or CRBN positive leukemia, wherein the proteolysis targeting chimeric molecule when n = 3 has excellent photoisomerization activity, and can be used for prepare a reagent or drug for degrading BCR-ABL and/or CRBN protein by light regulation. Also provided is a method for synthesizing this series of proteolysis targeting chimeric molecules. |