| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8adaddc602ad7cb7f9e2d550681bb36d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-148
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6888
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6811 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6874
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6811 |
| filingDate |
2020-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3af92ee06a157f66693c39f70b2890c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e03d6b8818f676825f645d23d1efd8f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a77baafd22dbf65b8e52a50fc2bf600
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a457d6dc0c2b91b5d7f2b186c3482dc |
| publicationDate |
2020-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020150705-A1 |
| titleOfInvention |
Dna methylation measurement for mammals based on conserved loci |
| abstract |
While methylation chips have 5 been widely used in human studies over the last ten years, methylation chips for non-human species have not, perhaps due to lack of sufficient demand and/or because species specific methylation chips may be suboptimal for cross-species comparisons. To address challenges in this technology, we developed an algorithm, Conserved Methylation Array Probe Selector (CMAPS), 10 which repurposes the degenerate base technology used to tolerate within-human variation to tolerate cross-species mutations. CMAPS performs a greedy search to obtain a maximal number of species that can be targeted using a probe for any CpG in the human genome, based on a multiple sequence alignment. CMAPS then ranks all the probes and chooses a final set so that arrays can be made that can query a large 15 number of mammalian species and varied genomic positions based on external annotations of exons, CpG islands and hyper versus hypo methylated regions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112397151-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022272120-A1 |
| priorityDate |
2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |