| abstract |
Chimeric proteins of two types of rhodopsin, ion transport type rhodopsin and G-protein-coupled receptor rhodopsin, and nucleic acids encoding said chimeric proteins are provided for preventing, and suppressing progression of, retinal disease, strengthening visual cognitive behavioral function (for example, improving brightness judgment function, improving brightness avoidance function and/or danger avoidance function) and enhancing visual function (for example, improving vision). The present invention further provides a method for preventing, or suppressing the progression of, retinal diseases, disorders or conditions in a subject, improving visual cognitive behavioral function (for example, improving brightness judgment function, improving brightness avoidance function and/or danger avoidance function), or strengthening visual function (for example, improving vision), and involves a step for dosing a subject with an effective amount of the nucleic acids that encode the ion transport-type receptor rhodopsin and G-protein-coupled receptor rhodopsin chimeric proteins. |