http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020147176-A1

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filingDate 2019-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd16a0ceee6086b1c9e3afc4437f1bc9
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publicationDate 2020-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020147176-A1
titleOfInvention Polypeptide having effect of inhibiting proliferation of leukemia cells
abstract Disclosed is a polypeptide having an effect of inhibiting the proliferation of leukemia cells, and the present invention specifically relates to the use of a polypeptide in a drug for treating leukemia. The polypeptide consists of 37 amino acids, with the amino acid sequence thereof being Lys-Glu-Ser-Met-Asp-Ala-Asn-Lys-Pro-Thr-Lys-Asn-Leu-Pro-Leu-Lys-Lys-Ile-Pro-Cys-Lys-Thr-Ser-Ala-Pro-Ser-Gln-Ser-Phe-Phe-Ala-Arg-Asp-Asn-Thr-Ala-Asn, and the N-terminus of the polypeptide being connected with myristic acid. The polypeptide prepared by the present invention can enter the leukemia cells by connecting with the myristic acid, thereby achieving the effect of inhibiting the proliferation of the leukemia cells.
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