| abstract |
Provided is a method for preparing sulfonamides which are inhibitors of Bcl-2/ Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl) -1-isopropyl-4-methylsulfonyl-5-methyI-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yI)-phenylam inosulfonyl)-2-trifluoromethylsulfonyl-anilino)-4-phenylthio-butyl)- 4- hydroxyl-piperidine. Also provided are intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use. |