http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020134022-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2019-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7621bb66c5dbc74ad542b37af2c2f5ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40d9ccbf9d761b7c319ee916b3049ce7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a67b00a2f0f988e4938e210959f0f60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b6d11932c46d98882789b7f57c5cfa1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a67687fb1ea4d1bf6a979c397a02f9ea |
| publicationDate | 2020-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020134022-A1 |
| titleOfInvention | Use of axitinib and analogs thereof in preparing blood-brain barrier permeability regulator |
| abstract | The present invention relates to the use of axitinib and analogs thereof in preparing a blood-brain barrier permeability regulator. The blood-brain barrier permeability regulator can reduce the permeability of the blood-brain barrier, and can promote the recovery of the blood-brain barrier function from a pathologically destroyed state to a state close to that of the physiological barrier. The axitinib and analogs thereof reduce the degree of down-regulation of a pathological blood-brain barrier tight junction protein Claudin-5/Occludin by inhibiting the vascular endothelial cell growth factor-phosphatidylinositol kinase-protein kinase B signaling pathway, thereby reducing the permeability of the blood-brain barrier. The blood-brain barrier permeability regulator can be used in the treatment of related diseases that cause changes in the permeability of the blood-brain barrier. |
| priorityDate | 2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.