| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7d424501f2cc71f68093d9721941954d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37b416a8c0d2b0f1c3d6026d932027af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c87b1f7158bec499783fa1b27aad08c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-507
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B25-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2818
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2019-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2029c6d29925327149e40809dc29b7ba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac49f320e5bc50ddb200f304eb61d1d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_701b0916e480656e70659f3a988486db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cff68a2088508819e4749ab8226467e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18d3abf9438d7f8307507c899fe2f6ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc5a9d330cba04cc10c5e0c85596570a |
| publicationDate |
2020-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020130948-A1 |
| titleOfInvention |
Method of predicting for benefit from immune checkpoint inhibition therapy |
| abstract |
The present invention relates to a method of identifying a cancer patient as benefiting or not benefiting from immune checkpoint inhibition therapy comprising measuring an expression level of one or more preselected markers in a cancerous biological sample obtained from the patient, identifying a differentially expressed alternative promoter based on the expression level of the one or more preselected markers, calculating an alternative promoter usage score (APB score) and identifying the patient as benefiting or not benefiting from immune checkpoint inhibition therapy using the APB score. In particular, patients with high APB score has lower expression of CD8A, granzyme A and perforin 1 and have worse progression-free survival than patients with low APB score. Patients with lower APB score have higher objective response rate as compared to patients with APB score. |
| priorityDate |
2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |