http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020129087-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1f59e06549f37649e7aa4bde5631d22 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C249-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C249-04 |
| filingDate | 2019-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79f2183dff8c2823ac4ddbc213e3eec9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_889e2624eb0b5abd9067127149cd6464 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6438331236d39aa3f45f42b306975c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7eca11190d0daeb6eb76d9214ca5abd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbdccb2cce6b1556ee69cadd3f6a1c2c |
| publicationDate | 2020-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020129087-A1 |
| titleOfInvention | NOVEL PROCESS FOR THE PREPARATION OF R-PHENYLACETYLCARBINOL AND β-AMINOALCOHOLS |
| abstract | Disclosed herein is a process for the manufacture of (R)-phenylacetylcarbinol ((R)-PAC), (1R,2S). Ephedrine and its salts, (1R,2S)-norephedrine and its salts and 1-(Phenyl/Substituted phenyl)-2-(amino/alkylamino/dialklyamino) propan-1-ol and its salts, by enzymatic reduction of α-isonitrosopropiophenone (INP) and substituted α-isonitrosopropiophenone (substituted INP). The β-amino alcohols, produced by the process of present invention gives their corresponding diastereomers on Walden inversion. The present preparation process of (R)-PAC with (R)-PAC oxime as an intermediate has the advantage, that propiophenone as a key raw material which is easily available and has a low-price, operationally simple with high yield and a single process leading to the synthesis of several 1,2-aminoalcohol/ β- aminoalcohols active pharmaceutical ingredients. The design approach of the process is to reduce environmental impact of the product by comparing to the present manufacturing process. |
| priorityDate | 2018-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 173.