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filingDate 2019-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2020-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020128898-A1
titleOfInvention Pharmaceutical combinations
abstract The present invention relates to the combination of the HDM2-p53 interaction inhibitor drug (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one [HDM201] and an anti-TIM-3 antibody molecule as TIM-3 inhibitor. The present invention further relates to the use of said combination in the treament of cancer, in particular hematological tumors. The present invention further relates to dose and dosing regimen related to this combination cancer treatment.
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http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226396494
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID738409
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395394
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226396495
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID4033
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395395
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCF6U272
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP26445

Total number of triples: 613.