| abstract |
The present disclosure relates to a compound of Formula (I): or anyone of its metabolites or a pharmaceutically acceptable salt thereof, for use for treating and/or preventing an inflammatory disease, disorder or condition, wherein each R is independently hydrogen, halogen, -CN, hydroxyl, (C 1 -C 3 )fluoroalkyl, (C 1 -C 3 )fluoroalkoxy, (C 3 -C 6 )cycloalkyl, -NO 2 , -NR 1 R 2 , (C 1 -C 4 )alkoxy, phenoxy, -NR 1 -SO 2 -NR 1 R 2 , -NR 1 -SO 2 -R 1 , -NR 1 -C(=O)-R 1 , -NR 1 -C(═O)-NR 1 R 2 , -SO 2 -NR 1 R 2 , -SO 3 H, -O- SO 2 -OR 3 , -O- P(═O)-(OR 3 )(OR 4 ), -O-CH 2 -COOR 3 , (C 1 -C 3 )alkyl; each R' is independently hydrogen, (C 1 -C 3 )alkyl, hydroxyl, halogen, -NO 2 , -NR 1 R 2 , morpholinyl, morpholino, N-methylpiperazinyl, (C 1 -C 3 )fluoroalkyl, (C 1 -C 4 )alkoxy, -O-P(═O)- (OR 3 )(OR 4 ), -CN, a -NH-SO 2 -N(CH 3 ) 2 group, or other groups. It further relates to A compound of formula (IV): or a pharmaceutically acceptable salt thereof, for use for treating and/or preventing an inflammatory disease, disorder or condition, wherein V, Z, R, R', n, and n' are as described above. |