| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_696e1bc591e0a3a8ddb175831611c825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e48e11f0ae2a45f5f38bccdfaba54fa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2013
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1617
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1623
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0095 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 |
| filingDate |
2018-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fce5d323ecf327506a34ede14c75a4e5 |
| publicationDate |
2020-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020121027-A1 |
| titleOfInvention |
Amorphous alprazolam compositions with anxiolytic activity with ethyl cellulose and crospovidone and corresponding methods |
| abstract |
The invention relates to an amorphous alprazolam composition with anxiolytic activity, which comprises: a) a premixture containing: 0.33-0.66% w/w alprazolam; 0.07-0.2% w/w ethyl cellulose as a binding agent; a disintegrating agent, a diluting agent, aspartame and a flavour masking agent; and b) the premixture combined with: 4-6% w/w water-insoluble crospovidone as a disintegrating agent; a lubricating agent; flavouring agents, sweetening agents and q.s. 100% granular mannitol as a diluent, wherein: the ratio of alprazolam to ethyl cellulose in the premixture is in the range of 2.5:1 to 5:1; the ratio of alprazolam to water-insoluble crospovidone is in the range of 0.06:1 to 0.13:1; and the degree of crystallinity of alprazolam is less than 10%. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113876961-A |
| priorityDate |
2018-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |