| abstract |
A nanocrystalline eye drop, a preparation method and a use thereof, which belong to the technical field of eye drops and solve a problem in the prior art in which a drug cannot enter the fundus and a vitreous injection is required. The nanocrystalline eye drop comprises a double-soluble macromolecule, a single-soluble macromolecule, and a fat-soluble drug. The double-soluble macromolecule and the single-soluble macromolecule interact with each other to encapsulate the fat-soluble drug to form and stabilize a nanocrystal. The drug can rapidly pass through a blood-eye barrier into the vitreous body by means of special intercellular space infiltration and/or pinocytosis, and achieve an effective therapeutic effect by means of passive targeting and attachment. Moreover, the drug is convenient to use. |