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filingDate 2019-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_192ac4339584d84db797fb6aff419b69
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publicationDate 2020-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020100954-A1
titleOfInvention (anti-cdh6 antibody)-(pyrrolobenzodiazepine derivative) conjugate
abstract The present invention addresses the problem of providing: an antibody which can bind specifically to CDH6 and has a high internalization activity; an antibody-drug conjugate which contains the antibody and has a high anti-tumor activity; a medicine which is prepared using the antibody-drug conjugate and has a therapeutic effect on tumors; a method for treating a tumor using the antibody, the antibody-drug conjugate or the medicine; and others.　According to the present invention, there are provided: an anti-CDH6 antibody which has an internalization activity; an (anti-CDH6 antibody)-drug conjugate which comprises the anti-CDH6 antibody and a novel PBD derivative bonded to each other and has a high anti-tumor activity; and a medicine and a method for treating a tumor, in each of which the anti-CDH6 antibody or the (anti-CDH6 antibody)-drug conjugate is used.
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priorityDate 2018-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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