| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ae2434a2e95fcd5b863b9975c1b5dbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_151c6f9cbc49e3b66d33292bc711612c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 |
| filingDate |
2019-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7348562694984de52f947441d84f6544
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_078e6cff2d1201ac873695c95a8dd87d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9891e78718c3d7e254e0b29643fdfcf7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_967efc92f0698fc16cdc8b0f8fc5df08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c78d74eab3998d96a1a052db8a8ca422 |
| publicationDate |
2020-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020089850-A1 |
| titleOfInvention |
Pharmaceutical compositions for the effective treatment of pancreatic cancer |
| abstract |
The present invention describes pharmaceutical compositions comprising compounds that have the formula and formula (compounds D14 and C22 respectively) that specifically inhibit the KRas4B- PDE6δ interaction, making them useful for the effective treatment of pancreatic cancer. The compounds of the invention stabilized the protein-protein interaction in the KRas4B-PDE6δ complex showing antineoplastic activity against pancreatic cancer cells, reduced the viability in the human pancreatic cancer cells but not in the normal pancreatic cells and induced cellular death via apoptosis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113387872-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113387872-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023041978-A1 |
| priorityDate |
2018-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |