| abstract |
The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11 -(4-fluorophenoxy)-1,10-dihydroxyundeca- 2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4). In particular, the invention features pharmaceutical compositions including compound (1) and the use of compound (1) for the treatment of a disorder (e.g., a fibrotic disorder or an inflammatory disorder, such as an autoimmune disorder) in a subject in need thereof. |