http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020086311-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 |
| filingDate | 2019-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efc72fd0ea3aec1a8f6cbb748491077b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c92d5896ee6257c2dafed8b3a744a2b1 |
| publicationDate | 2020-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020086311-A1 |
| titleOfInvention | Thiophosphorodichloridate reagents for chemoselective histidine bioconjugation |
| abstract | Proteins are labeled by contacting the protein with a thiophosphorodichloridate reagent under conditions to effect chemoselective histidine conjugation. This technology provides numerous applications, including probing and enhancing protein function using histidine-directed chemistry. For example, our bioconjugation strategy can be used to generate bioconjugates on polyhistidine tags commonly found in recombinant proteins, as well as on single histidine residues. These bioconjugates, such as antibody-drug conjugates, immobilized antibodies or enzymes, PEGylated proteins and so on, can be used in pharmaceutics and diagnostics. |
| priorityDate | 2018-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 423.