| abstract |
The present invention relates to a modified oligonucleotide and, more specifically, a pharmaceutical composition containing a modified oligonucleotide having the structure of the following chemical formula 1 or a pharmaceutically acceptable salt thereof has high in vivo stability and can exhibit an excellent anticancer effect. [Chemical formula 1] (N) x-[TGG] m[TTG][TGG] n-(M) y (In the formula, N and M are independently deoxyuridine (dU), deoxycytidine (dC), uridine (U) or cytidine (C), which has a halogen or a hydroxyl group coupled to the 5-position or the 2'-position, x and y are independently an integer of 0-10 (except when both x and y are 0), n is an integer of 1-10, and m is an integer of 1-10). |