http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020066270-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate | 2019-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_531f01a42c29ed230e1a6c06cd5b6bd0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_defd1f0856ee3369b14f193ef21972be |
| publicationDate | 2020-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020066270-A1 |
| titleOfInvention | METHOD FOR PRODUCING κ CHAIN VARIABLE REGION-CONTAINING ANTIBODY AND/OR ANTIBODY FRAGMENT |
| abstract | The purpose of the present invention is to provide a method for producing a κ chain variable region-containing antibody and/or antibody fragment at a high purity by efficiently separating the κ chain variable region-containing antibody and/or antibody fragment from a by-product derived from the antibody. The method according to the present invention for producing an antibody and/or antibody fragment, said antibody and/or antibody fragment containing a κ chain variable region, comprises: a step for contacting a liquid sample, which contains the aforesaid antibody and/or antibody fragment together with a light chain derivative and/or a heavy chain derivative, with an affinity separation matrix, in which protein L, etc. is immobilized as a ligand on an insoluble carrier, and thus adsorbing the antibody and/or antibody fragment on the ligand; a step for washing the affinity separation matrix on which the antibody and/or antibody fragment are adsorbed; and a step for separating the antibody and/or antibody fragment from the affinity separation matrix by elution with an eluent, said method being characterized in that, in the elution step, the pH of the eluent is continuously or gradually lowered. |
| priorityDate | 2018-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 106.