| abstract |
A BCMA-and-CD19 dual-target chimeric antigen receptor and uses thereof are provided. Specifically, provided is a polynucleotide sequence selected from the group consisting of: (1) a polynucleotide sequence comprising, as linked in sequence, sequences encoding an anti-BCMA and an anti-CD19 single chain antibodies, a sequence encoding the hinge region of human IgG4, a sequence encoding the transmembrane region of human CD28, a sequence encoding the intracellular domain of human 41BB, a sequence encoding the intracellular domain of human CD3ΞΆ and optionally a sequence encoding a fragment of EGFR comprising the extracellular domain III and the extracellular domain IV; and (2) a complementary sequence of the polynucleotide sequence of (1). Further provided are corresponding fusion proteins and vectors comprising the coding sequence, as well as uses of the fusion proteins and vectors. |