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filingDate 2019-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2020-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020060087-A1
titleOfInvention Highly efficient anti-tfpi antibody composition
abstract The present disclosure relates to a pharmaceutical highly efficient anti-TFPI antibody composition including an anti-TFPI antibody for treating hemophilia, in which the content of HCP in a drug substance is less than 10.0 ng/mg, and the content of LPA in the drug substance or the drug product is less than 1.0 ng/mg. According to the present disclosure, a highly efficient anti-TFPI antibody composition having very low contents of HCP and LPA may be provided by providing a separation/purification process capable of minimizing anti-TFPI antibody polymer generation, and may be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease.
priorityDate 2018-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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